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Microbes Infect. 2013 May;15(5):342-6. doi: 10.1016/j.micinf.2013.01.001. Epub 2013 Jan 14.

Cathelicidin LL-37 bloodstream surveillance is down regulated during septic shock.

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  • 1Emergency Medicine Department, University of São Paulo, Brazil.

Abstract

Host defense peptides are ancient weapons of the innate immunity. The human cathelicidin LL-37 protects the epithelial barrier against infection and is constitutively secreted in the bloodstream by immune cells. Current knowledge claims that LL-37 is up regulated upon infection. LL-37 can protect against bacterial infections and possesses many immunomodulatory properties. Here, we show that the human host defense peptide LL-37 is down regulated during septic shock. Furthermore, we show that these effects are not related to vitamin D serum levels, a potent inducer of LL-37 gene expression, pointing out the complex regulation of cathelicidins during septic shock.

Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

PMID:
23328115
[PubMed - indexed for MEDLINE]
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