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J Pediatr Endocrinol Metab. 2013;26(1-2):183-5. doi: 10.1515/jpem-2012-0372.

Hepatitis in an infant treated with octreotide for congenital hyperinsulinism.

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  • 1Armon Child Center, Haifa, Israel. ilanaza2@clalit.org.il


Congenital hyperinsulinism is characterized by hypoglycemia caused by several genetic disorders of inappropriate insulin secretion. Octreotide, an analogue of somatostatin, plays a major role in the pharmaceutical treatment of this condition. A 9-month-old infant treated with octreotide developed anicteric hepatitis with no other proven cause. After the discontinuation of this drug, the liver enzymes declined rapidly. Liver function tests should be followed in patients receiving octreotide.

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