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PLoS One. 2013;8(1):e53710. doi: 10.1371/journal.pone.0053710. Epub 2013 Jan 10.

The cancer stem cell marker CD133 interacts with plakoglobin and controls desmoglein-2 protein levels.

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  • 1Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Abstract

The pentaspan membrane glycoprotein CD133 (also known as prominin-1) has been widely used as a marker for both cancer and normal stem cells. However, the function of CD133 has not been elucidated. Here we describe a cancer stem cell line established from clear cell carcinoma of the ovary (CCC) and show that CD133 interacts with plakoglobin (also known as γ-catenin), a desmosomal linker protein. We further demonstrate that knockdown of CD133 by RNA interference (RNAi) results in the downregulation of desmoglein-2, a desmosomal cadherin, and abrogates cell-cell adhesion and tumorigenicity of CCC stem cells. We speculate that CD133 may be a promising target for cancer chemotherapy.

PMID:
23326490
[PubMed - indexed for MEDLINE]
PMCID:
PMC3542344
Free PMC Article
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