Format

Send to:

Choose Destination
See comment in PubMed Commons below
Anesthesiol Res Pract. 2012;2012:989487. doi: 10.1155/2012/989487. Epub 2012 Dec 26.

Brain temperature: physiology and pathophysiology after brain injury.

Author information

  • 1Department of Anesthesia and Critical Care, University Hospital of Toulouse, University Paul Sabatier, Toulouse, France.

Abstract

The regulation of brain temperature is largely dependent on the metabolic activity of brain tissue and remains complex. In intensive care clinical practice, the continuous monitoring of core temperature in patients with brain injury is currently highly recommended. After major brain injury, brain temperature is often higher than and can vary independently of systemic temperature. It has been shown that in cases of brain injury, the brain is extremely sensitive and vulnerable to small variations in temperature. The prevention of fever has been proposed as a therapeutic tool to limit neuronal injury. However, temperature control after traumatic brain injury, subarachnoid hemorrhage, or stroke can be challenging. Furthermore, fever may also have beneficial effects, especially in cases involving infections. While therapeutic hypothermia has shown beneficial effects in animal models, its use is still debated in clinical practice. This paper aims to describe the physiology and pathophysiology of changes in brain temperature after brain injury and to study the effects of controlling brain temperature after such injury.

PMID:
23326261
[PubMed]
PMCID:
PMC3541556
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Write to the Help Desk