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Clin Cosmet Investig Dermatol. 2013;6:1-21. doi: 10.2147/CCID.S39017. Epub 2013 Jan 8.

Characterization and evolution of dermal filaments from patients with Morgellons disease.

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  • 1International Lyme and Associated Diseases Society, Bethesda, MD, USA;

Abstract

Morgellons disease is an emerging skin disease characterized by formation of dermal filaments associated with multisystemic symptoms and tick-borne illness. Some clinicians hypothesize that these often colorful dermal filaments are textile fibers, either self-implanted by patients or accidentally adhering to lesions, and conclude that patients with this disease have delusions of infestation. We present histological observations and electron microscopic imaging from representative Morgellons disease samples revealing that dermal filaments in these cases are keratin and collagen in composition and result from proliferation and activation of keratinocytes and fibroblasts in the epidermis. Spirochetes were detected in the dermatological specimens from our study patients, providing evidence that Morgellons disease is associated with an infectious process.

KEYWORDS:

Borrelia burgdorferi; Lyme disease; Morgellons disease; collagen; digital dermatitis; fibroblasts; keratin; keratinocytes; spirochetes

PMID:
23326202
[PubMed]
PMCID:
PMC3544355
Free PMC Article
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