Abstract
A recent publication indicated that overexpression of Axl, a cellular receptor that negatively regulates Toll-like receptor signaling, enhanced the entry of viruses pseudotyped with the glycoprotein of lymphocytic choriomeningitis virus (LCMV) in vitro. In testing the biological relevance of these observations, we found differences in neither viral kinetics between LCMV infections of Axl(-/-) and wild-type mice nor T-cell responses prior to spontaneous viral clearance. Thus, Axl is not required for productive LCMV infection of mice.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Arenaviridae Infections / physiopathology*
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Arenavirus / metabolism*
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Arenavirus / physiology
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Axl Receptor Tyrosine Kinase
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Fluorescence
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / metabolism*
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Receptor Protein-Tyrosine Kinases / genetics
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Receptor Protein-Tyrosine Kinases / metabolism*
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Virus Internalization*
Substances
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Proto-Oncogene Proteins
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Receptor Protein-Tyrosine Kinases
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Axl Receptor Tyrosine Kinase