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Cell Res. 2013 Apr;23(4):452-4. doi: 10.1038/cr.2013.5. Epub 2013 Jan 15.

Fox family ties.

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  • 1Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.


The transcription factor Foxp3 plays an indispensible role in the differentiation of regulatory T (Treg) cells and the expression of their suppressive functions. In a recent article published in Nature, Ouyang et al. demonstrate that Treg cell differentiation is also enabled by transcriptional networks controlled by another Forkhead box family member, Foxo1.

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