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Front Immunol. 2013 Jan 4;3:403. doi: 10.3389/fimmu.2012.00403. eCollection 2012.

Consequences of the crosstalk between monocytes/macrophages and natural killer cells.

Author information

  • 1Laboratory of Immunogenetics and Allergology, Centre de Recherche Public de la Santé Luxembourg, Luxembourg.

Abstract

The interaction between natural killer (NK) cells and different other immune cells like T cells and dendritic cells is well-described, but the crosstalk with monocytes or macrophages and the nature of ligands/receptors implicated are just emerging. The macrophage-NK interaction is a major first-line defense against pathogens (bacteria, viruses, fungi, and parasites). The recruitment and the activation of NK cells to perform cytotoxicity or produce cytokines at the sites of inflammation are important to fight infections. The two main mechanisms by which macrophages can prime NK cells are (1) activation through soluble mediators such as IL-12, IL-18, and (2) stimulation through direct cell-to-cell contact. We will discuss the progress in matters of modulation of NK cell functions by monocytes and macrophages, in the steady state and during diseases.

KEYWORDS:

NK cells; activation; cytokines; infection; macrophages; monocytes; receptors

PMID:
23316194
[PubMed]
PMCID:
PMC3539656
Free PMC Article
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