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Nat Med. 2013 Feb;19(2):238-40. doi: 10.1038/nm.3052. Epub 2013 Jan 13.

Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure.

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  • 1Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Abstract

Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 μm (lateral) × 7 μm (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.

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