Send to:

Choose Destination
See comment in PubMed Commons below
Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 1):2372-4. doi: 10.1016/j.neubiorev.2013.01.008. Epub 2013 Jan 11.

Depressive disorders and suicide: Epidemiology, risk factors, and burden.

Author information

  • 1Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain; Department of Psychiatry, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IP), Universidad Autónoma de Madrid, Spain.


The social and economic impact of mood disorders and suicide is extremely high and may be even higher in coming years, and yet, research in mental health is largely underfunded. This report summarizes the most recent data concerning the epidemiology and burden of depression and suicide, and underlines the most recent initiatives to identify the barriers to effective treatment and prevention of mood disorders. Global cooperation and networks of research networks are proposed. Progress in the understanding of the pathophysiology and subtypes of depression, technological advances, emphasis on early prediction of response and prevention, and a paradigm shift in drug development are crucial to overcome the current challenges posed by increasing rates of depression and suicide.

Copyright © 2013 Elsevier Ltd. All rights reserved.


Bipolar disorder; Burden; Depression; Drug development; Research; Suicide

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk