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Biochim Biophys Acta. 2013 Jul;1832(7):998-1004. doi: 10.1016/j.bbadis.2013.01.005. Epub 2013 Jan 9.

Dendritic cells and liver fibrosis.

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  • 1Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY, USA.

Abstract

Dendritic cells are a relative rare population of specialized antigen presenting cells that are distributed through most lymphoid and non-lymphoid tissues and play a critical role in linking the innate and adaptive arms of the immune system. The liver contains a heterogeneous population of dendritic cells that may contribute to liver inflammation and fibrosis through a number of mechanisms. This review summarizes current knowledge on the development and characterization of liver dendritic cells and their potential impact on liver fibrosis. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease.

Copyright © 2013 Elsevier B.V. All rights reserved.

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