Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Cell Biol. 2013 Apr;25(2):247-53. doi: 10.1016/j.ceb.2012.12.006. Epub 2013 Jan 10.

The Hippo superhighway: signaling crossroads converging on the Hippo/Yap pathway in stem cells and development.

Author information

  • 1Stem Cell Program, Chidren's Hospital, Boston, MA 02115, United States.

Abstract

Tissue regeneration is vital to the form and function of an organ. At the core of an organs' ability to self-renew is the stem cell, which maintains homeostasis, and repopulates injured or aged tissue. Tissue damage can dramatically change the dimensions of an organ, and during regeneration, an organ must halt growth once the original tissue dimensions have been restored. Therefore, stem cells must give rise to the appropriate number of differentiated progeny to achieve homeostasis. How this tissue-size checkpoint is regulated and how tissue size information relayed to stem cell compartments is unclear, however, it is likely that these mechanisms are altered during the course of tumorigenesis. An emerging signaling cascade, the Hippo Signaling Pathway, is a broadly conserved potent organ size regulator [1]. However, this pathway does not act alone. A number of examples demonstrate crosstalk between Hippo and other signaling pathways including Wnt, Tgfβ and Notch, with implications for stem cell biology. Here, we focus on these interactions primarily in the context of well characterized stem cell populations.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PMID:
23312716
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk