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Science. 2013 Jan 11;339(6116):172-7. doi: 10.1126/science.1230721.

Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis.

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  • 1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA.

Abstract

Metabolism and immunity are inextricably linked both to each other and to organism-wide function, allowing mammals to adapt to changes in their internal and external environments. In the modern context of obesogenic diets and lifestyles, however, these adaptive responses can have deleterious consequences. In this Review, we discuss the pleiotropic actions of inflammation and insulin resistance in metabolic homeostasis and disease. An appreciation of the adaptive context in which these responses arose is useful for understanding their pathogenic actions in disease.

PMID:
23307735
[PubMed - indexed for MEDLINE]
PMCID:
PMC3725457
Free PMC Article
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