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Int J Infect Dis. 2013 Jun;17(6):e379-84. doi: 10.1016/j.ijid.2012.11.027. Epub 2013 Jan 8.

Early-onset and late-onset group B streptococcal disease in Japan: a nationwide surveillance study, 2004-2010.

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  • 1Department of Pediatrics, Nishi-Kobe Medical Center, 5-7-1 Kojidai, Nishi-ku, Kobe 651-2273, Japan. kskmatsu@s4.dion.ne.jp

Abstract

OBJECTIVES:

To clarify the incidence and prognosis of early-onset (EOD) and late-onset (LOD) GBS disease in Japan. To evaluate the influence of national guidelines issued in 2008 on the epidemiology of GBS disease.

METHODS:

Retrospective nationwide questionnaire surveillance on culture-confirmed GBS infections between 2004 and 2010.

RESULTS:

Eighty-eight EOD and 162 LOD cases were reported from 152 participating hospitals. The case fatality of EOD was 13.6% and of LOD was 8.0%. Premature birth <37 weeks (p<0.001) and low birth weight <2500 g (p<0.001) were significantly associated with EOD mortality. A high rate of neurological sequelae was noted in meningitis in EOD (8/24) and LOD (29/85) cases. Based on a live-birth number of 438359 and inborn case numbers of 36 EOD and 42 LOD, the incidence of EOD and LOD were estimated to be 0.08 (95% confidence interval (CI) 0.06-0.11)/1000 and 0.10 (95% CI 0.07-0.12)/1000 live-births, respectively. Before (2004-2008) and after (2009-2010) the issue of guidelines, the mortality of EOD (from 14.8% to 11.8%) and LOD (from 9.8% to 2.5%) improved, but the incidence was unchanged.

CONCLUSIONS:

The incidence of EOD and LOD is apparently low in Japan, but the mortality and morbidity rates remain substantial. The issue of national guidelines did not affect the incidence.

Copyright © 2012 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

PMID:
23305911
[PubMed - indexed for MEDLINE]
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