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J Neuroimmunol. 2013 Mar 15;256(1-2):55-61. doi: 10.1016/j.jneuroim.2012.12.001. Epub 2013 Jan 8.

Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis.

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  • 1Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Road, Guangzhou 510080, China.

Abstract

Growing evidence has demonstrated that dysfunction of follicular helper T (TFH) cells results in an abnormal positive selection of autoreactive B cells, which contributes to the development of autoimmune diseases. This study reveals that the frequency of circulating counterparts of TFH cells in myasthenia gravis (MG) patients is significantly higher compared to healthy controls. Interestingly, the frequencies of circulating TFH cells were positively correlated with the levels of serum anti-AChR Ab in MG patients. Our data suggest the presence of overactivation and expansion of circulating counterparts of TFH cells in MG patients, which may contribute to the immunopathogenesis of MG.

Copyright © 2012 Elsevier B.V. All rights reserved.

PMID:
23305745
[PubMed - indexed for MEDLINE]
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