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Artif Cells Nanomed Biotechnol. 2013 Aug;41(4):227-31. doi: 10.3109/21691401.2012.749482. Epub 2013 Jan 10.

Preparation and evaluations in vitro of oxaliplatin polylactic acid nanoparticles.

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  • 1Faculty of Pharmacy, Medical College of Qingdao University, Qingdao, P.R. China.


The oxaliplatin nanoparticles were prepared with polylactic acid matrix, orthogonal test was applied to optimize the prescriptions, and the qualities of oxaliplatin nanoparticles were characterized by the shape, particle size, encapsulation efficiency (EE), and drug loading (DL). Oxaliplatin nanoparticle was prepared by solution replacement method. The formation of 0.25% Tween80, DMF-water 1:8 (v/v), oxaliplatin-polylactic acid 1:5 (w/w), and 20 mg/ml polylactic acid showed the suitable EE (17.4 ± 0.47%), DL (3.52 ± 0.07%). We observed the shape of oxaliplatin nanoparticles through SEM. The average size of the particles was 120.5 ± 8.7 nm, which was detected by N5 submicron particle size analyzer.

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