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Evid Based Complement Alternat Med. 2012;2012:781280. doi: 10.1155/2012/781280. Epub 2012 Oct 31.

The Dual Antimelanogenic and Antioxidant Activities of the Essential Oil Extracted from the Leaves of Acorus macrospadiceus (Yamamoto) F. N. Wei et Y. K. Li.

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  • 1Department of Medical Laboratory Science and Biotechnology, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.


The antimelanogenic and antioxidant activities of the essential oil extracted from the leaves of Acorus macrospadiceus (Yamamoto) F. N. Wei et Y. K. Li have never been explored. The essential oil effectively inhibited mushroom tyrosinase activity (EC(50) = 1.57 mg/mL) and B16F10 tyrosinase activity (IC(50) = 1.01 mg/mL), decreased the melanin content (EC(50) = 1.04 mg/mL), and depleted the cellular level of the reactive oxygen species (ROS) (EC(50) = 1.87 mg/mL). The essential oil effectively scavenged 2,2-diphenyl-1-picryl-hydrazyl (DPPH) (EC(50) = 0.121 mg/mL) and 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) ABTS(+) radicals (EC(50) = 0.122 mg/mL). It also exhibited an apparent reducing power (EC(50) = 0.021 mg/mL) and metal-ion chelating activity (EC(50) = 0.029 mg/mL). The chemical constituents of the essential oil are ethers (55.73%), ketones (19.57%), monoterpenes (7.82%), alcohols (3.85%), esters (3.77%), sesquiterpenes (3.72%), and aromatic compounds (2.85%). The results confirm that A. macrospadiceus essential oil is a natural antioxidant and inhibitor of melanogenesis.

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