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Open Biol. 2013 Jan 8;3(1):120143. doi: 10.1098/rsob.120143.

L-form bacteria, cell walls and the origins of life.

Author information

  • The Centre for Bacterial Cell Biology, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne NE2 4AX, UK. jeff.errington@newcastle.ac.uk

Abstract

The peptidoglycan wall is a defining feature of bacterial cells and was probably already present in their last common ancestor. L-forms are bacterial variants that lack a cell wall and divide by a variety of processes involving membrane blebbing, tubulation, vesiculation and fission. Their unusual mode of proliferation provides a model for primitive cells and is reminiscent of recently developed in vitro vesicle reproduction processes. Invention of the cell wall may have underpinned the explosion of bacterial life on the Earth. Later innovations in cell envelope structure, particularly the emergence of the outer membrane of Gram-negative bacteria, possibly in an early endospore former, seem to have spurned further major evolutionary radiations. Comparative studies of bacterial cell envelope structure may help to resolve the early key steps in evolutionary development of the bacterial domain of life.

PMID:
23303308
[PubMed - indexed for MEDLINE]
PMCID:
PMC3603455
Free PMC Article

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