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Dermatol Surg. 2013 Jan;39(1 Pt 2):155-64. doi: 10.1111/dsu.12071.

Comparative study of biological activity of four botulinum toxin type A preparations in mice.

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  • 1Department of Rehabilitation Medicine, St. Paul's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.

Abstract

BACKGROUND:

Units of available botulinum toxin preparations are not interchangeable, and the dose-conversion ratios between such preparations remain controversial.

OBJECTIVE:

To compare the efficacy and safety of four botulinum toxin type A preparations.

MATERIALS AND METHODS:

Murine gastrocnemius compound muscle action potentials (CMAPs) were recorded before and after injecting the four botulinum toxin preparations (onabotulinumtoxinA, abobotulinumtoxinA, new botulinum toxin, and incobotulinumtoxinA).

RESULTS:

In all preparations, CMAP amplitudes decreased until 4 days after receiving the injection and then gradually recovered. On postinjection day 84, the amplitudes returned to baseline in all groups except the high-dose groups. CMAP amplitude in the contralateral limb also decreased up to postinjection days 4 to 7 and then gradually returned to baseline by postinjection day 28.

CONCLUSION:

The dose-conversion ratio between onabotulinumtoxinA and abobotulinumtoxinA was determined to be 1:2.6; previous reports of 1:3 were considered too high. A dose-conversion ratio between onabotulinumtoxinA and new botulinum toxin of 1:1 was deemed appropriate. OnabotulinumtoxinA and incobotulinumtoxinA demonstrated a dose-conversion ratio of 1:1.07. The efficacy of incobotulinumtoxinA was slightly lower than that of onabotulinumtoxinA. These dose-conversion ratios are applicable solely from an efficacy standpoint and not for safety. This study was conducted in mice, so it may not translate perfectly to human applications.

© 2012 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.

[PubMed - indexed for MEDLINE]
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