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Curr Oncol. 2012 Dec;19(6):324-8. doi: 10.3747/co.19.1175.

Ubiquitin pathway and ovarian cancer.

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  • 1Department of Gynecology and Obstetrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China.

Erratum in

  • Curr Oncol. 2013 Jun;20(3):e280.

Abstract

The ubiquitin-proteasome pathway is a common cellular process in eukaryotic tissue. Ubiquitin binds to proteins and tags them for destruction; this tagging directs proteins to the proteosome in the cell that degrades and recycles unneeded proteins. The ubiquitin-proteasome pathway plays an important role in the regulation of cellular proteins with respect to cell cycle control, transcription, apoptosis, cell adhesion, angiogenesis, and tumour growth. This review article discusses the various ways that the ubiquitin pathway is involved in ovarian cancer, such as modulating the ovarian-cancer-related gene BRCA1 and tumour suppressor p53, and interfering with the erk pathway, the cyclin-dependent cell cycle regulation process, and ERBB2 gene expression.

KEYWORDS:

Ubiquitin; gene expression; ovarian cancer; protein degradation; therapy

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