Display Settings:


Send to:

Choose Destination
J Invest Dermatol. 2013 Jan;133(1):9-11. doi: 10.1038/jid.2012.411.

TGFβ1, an epidermal controller of skin dendritic cell homeostasis.

Author information

  • 1Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.


Transforming growth factor-β1 (TGFβ1) is generally regarded as an anti-inflammatory cytokine. However, previous studies suggest that TGFβ1 can promote immune responses under certain conditions. In this issue, Mohammed et al. report that epidermal keratinocyte-derived TGFβ1 alone can alter homeostasis of multiple cutaneous dendritic cell (DC) subsets, which may enhance skin inflammation. These findings may provide a better understanding of the pathogenesis of inflammatory skin disorders such as psoriasis, although how keratinocyte-derived TGFβ1 regulates cutaneous DCs under physiological and inflammatory conditions should be further addressed.

Comment on

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk