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Hum Vaccin Immunother. 2013 Mar;9(3):707-11. Epub 2013 Jan 7.

Economic benefits of inactivated influenza vaccines in the prevention of seasonal influenza in children.

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  • 1Department of Public Health; School of Medicine; University of Barcelona; Barcelona, Spain; Public Health Agency of Catalonia; Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP); Madrid, Spain.


The aim of this study was to systematically review published studies that evaluated the efficiency of inactivated influenza vaccination in preventing seasonal influenza in children. The vaccine evaluated was the influenza-inactivated vaccine in 10 studies and the virosomal inactivated vaccine in 3 studies. The results show that yearly vaccination of children with the inactivated influenza vaccine saves money from the societal and family perspectives but not from the public or private provider perspective. When vaccination does not save money, the cost-effectiveness ratios were very acceptable. It can be concluded, that inactivated influenza vaccination of children is a very efficient intervention.


cost-benefit; cost-effectiveness; cost-utility; economic evaluation; efficiency; influenza vaccination

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