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J Am Chem Soc. 2013 Feb 6;135(5):1629-40. doi: 10.1021/ja3094313. Epub 2013 Jan 16.

The revolution and evolution of shotgun proteomics for large-scale proteome analysis.

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  • 1Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines, SR11, LaJolla, California 92037, United States.


Mass spectrometry has evolved at an exponential rate over the last 100 years. Innovations in the development of mass spectrometers have created powerful instruments capable of analyzing a wide range of targets, from rare atoms and molecules to very large molecules, such as a proteins, protein complexes, and DNA. These performance gains have been driven by sustaining innovations, punctuated by the occasional disruptive innovation. The use of mass spectrometry for proteome analysis was driven by disruptive innovations that created a capability for large-scale analysis of proteins and modifications.

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