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Biosens Bioelectron. 2013 May 15;43:101-7. doi: 10.1016/j.bios.2012.10.071. Epub 2012 Nov 9.

NTA-modified carbon electrode as a general relaying substrate to facilitate electron transfer of SOD: application to in vivo monitoring of O2(-) in a rat brain.

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  • 1State Key Laboratory of Pollution Control and Resources Reuse, Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, People's Republic of China.


Nitrilotriacetic acid (NTA)/histidine-tag (HT) technology has been first employed to facilitate the electron transfer of superoxide dismutase (SOD), and further been developed for in vivo monitoring of superoxide anion (O2(-)) in a rat brain during cerebral ischemia/reperfusion processes. Direct electron transfer of SOD is greatly enhanced at NTA-modified electrode with a high rate constant (ks) of 24±1.1s(-1). The formal potential (E(0)') of SOD is estimated to be 5±2.5mV vs. Ag

Copyright © 2012 Elsevier B.V. All rights reserved.

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