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Technol Cancer Res Treat. 2013 Jun;12(3):199-206. doi: 10.7785/tcrt.2012.500313. Epub 2012 Dec 26.

Computer-assisted, atlas-based segmentation for target volume delineation in whole pelvic IMRT for prostate cancer.

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  • 1Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.

Abstract

The purpose of this study is to evaluate whether computer-assisted segmentation is clinically feasible in target volume delineation for prostate cancer patients treated with whole pelvic IMRT. An atlas was created, comprised of 44 clinically node-negative prostate cancer patients. Three regions of interest (ROIs) were chosen for analysis: prostate, pelvic lymph nodes, and rectum. For a separate tester set of 15 patients with previously contoured ROIs by three experienced physicians, atlas-assisted contours were compared to manual contours by calculating a volumetric overlap index. In the tester set patients, the average overlap between the manually drawn and atlas-based contours for the prostate, pelvic lymph nodes, and rectum was 60%, 51%, and 64%, respectively. The volume differences were significant in the rectum and pelvic lymph nodes (p = 0.049 and p = 0.016, respectively); this was not true for the prostate. A subset analysis based on physician-specific atlases showed that the average overlap index for the pelvic lymph nodal volume increased from 51% to 60%, while the other ROIs had no significant changes. Despite significant inter-physician differences, atlas-based segmentation for pelvic lymph node delineation serves as an initial guideline for physicians, potentially improving both consistency and efficiency in contouring.

PMID:
23289478
[PubMed - indexed for MEDLINE]
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