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Blood. 2013 Jan 3;121(1):26-8. doi: 10.1182/blood-2012-07-444851.

Sense and nonsense of high-dose cytarabine for acute myeloid leukemia.

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  • 1Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.


High-dose cytarabine applied during remission induction or as consolidation after attainment of a complete remission has become an established element in the treatment of adults with acute myeloid leukemia. Recent evidence has challenged the need for these exceptionally high-dose levels of cytarabine. In this review, we present a reappraisal of the usefulness of high-dose cytarabine for acute myeloid leukemia treatment.

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