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J Clin Diagn Res. 2012 Nov;6(9):1571-3. doi: 10.7860/JCDR/2012/4744.2566.

Can vitamin B-complex aggravate the carbamazepine induced toxic epidermal necrolysis?

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  • 1Postgraduate Student, Postgraduate Student, Department of Pharmacology, Goa Medical College , India.


Toxic Epidermal Necrolysis (TEN), which is also known as Lyell's syndrome, is a widespread, life-threatening, mucocutaneous disease that is particularly observed secondary to drugtaking and less commonly secondary to infections and immunization. Carbamazepine is associated with benign pruritic rash in 10-15% of the patients, but the life threatening dermatological syndromes like exfoliative dermatitis, erythema multiforme, the Stevens-Johnson Syndrome (SJS) and TEN are rarely seen with the carbamazepine treatment. The 32 year old female suffering from chronic backache, who was prescribed carbamazepine along with an intravenous combination of vitamin B-complex and calcium, developed fever, cough and mucocutaneous manifestations of TEN after 15 days of the treatment. She was treated in the hospital with systemic steroids, intravenous immunoglobulins, antibiotics, intravenous fluids and supportive care. In spite of the above treatment, the patient could not survive for more than seven days.


Carbamazepine; Drug reaction; Systemic steroids; Toxic epidermal necrolysis

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