Send to

Choose Destination
See comment in PubMed Commons below
Mod Rheumatol. 2013 Nov;23(6):1186-91. doi: 10.1007/s10165-012-0818-3. Epub 2013 Jan 3.

Expression of CD44 in articular cartilage is associated with disease severity in knee osteoarthritis.

Author information

  • 1Department of Orthopaedics, Xiangya Hospital, Central South University, #87 Xiangya Road, 410008, Changsha, Hunan, China.



To investigate CD44 levels in articular cartilage of knee osteoarthritis (OA) and the relationship between CD44 and severity of the disease.


All 50 cartilage tissues included normal and OA cartilage, and were ascribed to the following four groups on the basis of modified Mankin score: normal, mild lesions, moderate lesions and severe lesions. CD44 levels in articular cartilage were assessed by immunohistochemical methods.


CD44 levels were detected in all four groups. The difference in average gray value of CD44 expression showed statistical significance when compared between each group (P < 0.05). In addition, CD44 expression in each group correlated with disease severity, according to the modified Mankin score (ρ = -0.848, P < 0.01).


CD44 in articular cartilage is associated with progressive knee OA joint damage.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Write to the Help Desk