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Mod Rheumatol. 2013 Nov;23(6):1186-91. doi: 10.1007/s10165-012-0818-3. Epub 2013 Jan 3.

Expression of CD44 in articular cartilage is associated with disease severity in knee osteoarthritis.

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  • 1Department of Orthopaedics, Xiangya Hospital, Central South University, #87 Xiangya Road, 410008, Changsha, Hunan, China.

Abstract

OBJECTIVES:

To investigate CD44 levels in articular cartilage of knee osteoarthritis (OA) and the relationship between CD44 and severity of the disease.

METHODS:

All 50 cartilage tissues included normal and OA cartilage, and were ascribed to the following four groups on the basis of modified Mankin score: normal, mild lesions, moderate lesions and severe lesions. CD44 levels in articular cartilage were assessed by immunohistochemical methods.

RESULTS:

CD44 levels were detected in all four groups. The difference in average gray value of CD44 expression showed statistical significance when compared between each group (P < 0.05). In addition, CD44 expression in each group correlated with disease severity, according to the modified Mankin score (ρ = -0.848, P < 0.01).

CONCLUSIONS:

CD44 in articular cartilage is associated with progressive knee OA joint damage.

[PubMed - indexed for MEDLINE]
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