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Luminescence. 2013 Nov-Dec;28(6):882-7. doi: 10.1002/bio.2451. Epub 2012 Dec 26.

A simple and sensitive spectrofluorimetric method for the determination of furosemide using zinc(II)-1,4-bis(imidazol-1-ylmethyl)benzene complexes.

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  • 1Education Ministry Key Laboratory on Luminescence and Real-Time Analysis, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, People's Republic of China.


A novel spectrofluorometric method for the determination of furosemide (FUR) is described. The method is based on enhancement of fluorescence emission of FUR in the presence of zinc (II) complexes of 1,4-bis(imidazol-1-ylmethyl)benzene. Under optimum conditions, the enhanced fluorescence intensity is linearly related to the concentration of FUR. The proposed method has been successfully applied to the determination of FUR in pharmaceutical preparations. The possible mechanism of this reaction is discussed briefly based on data from fluorescence spectroscopy, UV-vis absorption and infrared spectroscopy.

Copyright © 2012 John Wiley & Sons, Ltd.


1,4-bis(imidazol-1-ylmethyl)benzene (bix); FUR; fluorescence increasing; spectrofluorometry

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