A simple and sensitive spectrofluorimetric method for the determination of furosemide using zinc(II)-1,4-bis(imidazol-1-ylmethyl)benzene complexes

Yali Liu; Huijuan Wang; Jian Wang; Yuanfang Li

doi:10.1002/bio.2451

A simple and sensitive spectrofluorimetric method for the determination of furosemide using zinc(II)-1,4-bis(imidazol-1-ylmethyl)benzene complexes

Luminescence. 2013 Nov-Dec;28(6):882-7. doi: 10.1002/bio.2451. Epub 2012 Dec 26.

Authors

Yali Liu¹, Huijuan Wang, Jian Wang, Yuanfang Li

Affiliation

¹ Education Ministry Key Laboratory on Luminescence and Real-Time Analysis, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, People's Republic of China.

PMID: 23281175
DOI: 10.1002/bio.2451

Abstract

A novel spectrofluorometric method for the determination of furosemide (FUR) is described. The method is based on enhancement of fluorescence emission of FUR in the presence of zinc (II) complexes of 1,4-bis(imidazol-1-ylmethyl)benzene. Under optimum conditions, the enhanced fluorescence intensity is linearly related to the concentration of FUR. The proposed method has been successfully applied to the determination of FUR in pharmaceutical preparations. The possible mechanism of this reaction is discussed briefly based on data from fluorescence spectroscopy, UV-vis absorption and infrared spectroscopy.

Keywords: 1,4-bis(imidazol-1-ylmethyl)benzene (bix); FUR; fluorescence increasing; spectrofluorometry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Coordination Complexes / chemistry*
Furosemide / analysis*
Imidazoles / chemistry*
Molecular Structure
Spectrometry, Fluorescence / instrumentation
Spectrometry, Fluorescence / methods*
Tablets

Substances

Coordination Complexes
Imidazoles
Tablets
Furosemide