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Ann N Y Acad Sci. 2012 Dec;1275:107-13. doi: 10.1111/j.1749-6632.2012.06843.x.

Experimental myasthenia gravis in Aire-deficient mice: a link between Aire and regulatory T cells.

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  • 1Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.

Abstract

Aire (autoimmune regulator) has a key role in the establishment of tolerance to autoantigens. Aire(-/-) mice present decreased thymic expression of AChR, significantly lower frequencies of regulatory T (T(reg)) cells, and higher expression of Th17 markers, compared to controls. We therefore predicted that Aire(-/-) mice would be more susceptible to induction of experimental autoimmune myasthenia gravis (EAMG). However, when EAMG was induced in young mice, Aire(-/-) mice presented a milder disease that wild-type (WT) controls. In contrast, when EAMG was induced in older mice, Aire(-/-) mice were more severely affected than WT mice. The relative resistance to EAMG in young Aire(-/-) mice correlated with increased numbers of T(reg) cells in their spleens compared to young controls. A similar age-related susceptibility was also observed when EAE was induced in Aire(-/-) mice, suggesting an age-related link among Aire, disease susceptibility, and peripheral T(reg) cells that may be a general feature of autoimmunity.

© 2012 New York Academy of Sciences.

[PubMed - indexed for MEDLINE]
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