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Anim Genet. 2013 Aug;44(4):408-12. doi: 10.1111/age.12016. Epub 2012 Dec 25.

Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10.

Author information

  • 1Animal Genomics Laboratory, School of Agriculture and Food Science, University College Dublin, Dublin, Ireland; Section of Veterinary Clinical Sciences, School of Veterinary Medicine, University College Dublin, Dublin, Ireland.


Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).

© 2012 The Authors, Animal Genetics © 2012 Stichting International Foundation for Animal Genetics.


Equus caballus; Orthopaedic disease; SNP

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