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Int J Ophthalmol. 2012;5(6):726-30. doi: 10.3980/j.issn.2222-3959.2012.06.14. Epub 2012 Dec 18.

Angiogenesis-related cytokines in serum of proliferative diabetic retinopathy patients before and after vitrectomy.

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  • 1Department of Ophthalmology, the Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430014, Hubei Province, China.

Abstract

AIM:

To evaluate serum concentrations of angiogenesis-related cytokines in proliferative diabetic retinopathy (PDR) before and after vitrectomy.

METHODS:

Serum samples were collected from 30 PDR patients with varying severity before and after vitrectomy. Serum concentrations of vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), interleukin-8 (IL-8) and interferon-inducible protein-10 (IP-10) were determined by enzyme-linked immunosorbent assays (ELISA).

RESULTS:

Serum concentrations of VEGF, PEDF, IL-8 and IP-10 were significantly higher in PDR patients than that in controls, respectively (P<0.05). VEGF concentration decreased significantly in postoperative samples than that in preoperative samples (P<0.05). The concentrations of PEDF, IL-8 and IP-10 did not exhibit significant changes after vitrectomy.

CONCLUSION:

Elevated cytokines levels in serum may be diagnostically useful in PDR. Angiogenesis-related cytokines play important roles in the development of PDR, and would instruct the risk assessment of pathogenetic condition in PDR patients.

KEYWORDS:

angiogenesis; cytokine; enzyme-linked immunosorbent assay; proliferative diabetic retinopathy; vitrectomy

PMID:
23275908
[PubMed]
PMCID:
PMC3530816
Free PMC Article

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