Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
J Nerv Ment Dis. 2013 Jan;201(1):36-42. doi: 10.1097/NMD.0b013e31827ab24b.

Catatonia and neuroleptic malignant syndrome: two disorders on a same spectrum? Four case reports.

Author information

  • 1Department of Psychiatry, Neurobiology, Pharmacology and Bio-technologies, University of Pisa, Pisa, Italy.


We present the history of four bipolar patients who developed neuroleptic malignant syndrome (NMS) after antipsychotic treatment, focusing on the relationship between NMS and catatonia. In all cases, the administration of antipsychotics has been suspended as soon as fever and autonomic disturbances occurred. A supportive therapy was initiated to stabilize general conditions, then every patient started electroconvulsive therapy (ECT) in combination with benzodiazepines (BDZ). The risk of complications was reduced by the quick adoption of supportive care, whereas the combination of ECT and BDZ was effective in resolving the clinical picture. These cases may provide further support to the hypothesis that catatonia and NMS are disorders pertaining to the same spectrum of illness because the onset or exacerbation of catatonic symptoms coincided with the administration of antipsychotics. Our experience confirms the efficacy and safety of ECT in combination with BDZ as treatment of NMS and residual catatonia.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk