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Immunity. 2013 Jan 24;38(1):79-91. doi: 10.1016/j.immuni.2012.12.001. Epub 2012 Dec 27.

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.

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  • 1Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.

Erratum in

  • Immunity. 2013 May 23;38(5):1073-9.

Abstract

Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manipulation of these cells could bear therapeutic potential. However, specific ontogenies of individual populations and the overall functional organization of this cellular network are not well defined. Here we report a fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression. We have demonstrated that major tissue-resident macrophage populations, including liver Kupffer cells and lung alveolar, splenic, and peritoneal macrophages, are established prior to birth and maintain themselves subsequently during adulthood independent of replenishment by blood monocytes. Furthermore, we have established that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly6C(-) cells and that the abundance of Ly6C(+) blood monocytes dynamically controls the circulation lifespan of their progeny.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23273845
[PubMed - indexed for MEDLINE]
PMCID:
PMC3908543
Free PMC Article
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