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Immunol Lett. 2013 Feb;150(1-2):48-53. doi: 10.1016/j.imlet.2012.12.008. Epub 2012 Dec 22.

Depletion of IL-22 during culture enhanced antigen-driven IFN-γ production by CD4(+)T cells from patients with active TB.

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  • 1Department of Chemistry, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Abstract

In this study, we mainly investigated the expression of IFN-γ and IL-22-producing CD4(+)T cells, the relationship between the two cytokines in human tuberculosis. We showed that IFN-γ and IL-22 were induced by human mycobacterial infection. Besides, CD4(+)T cells expressing IFN-γ and IL-22 were significantly elevated following PPD stimulation. In addition, IFN-γ and IL-22 -expressing CD4(+)T cells were distinct from each other. We also found that there was a reciprocal relationship between IFN-γ and IL-22 production. The production of IL-22 was markedly enhanced in the absence of IFN-γ, also, the expression of IFN-γ was increased when the IL-22 signaling was inhibited by monoclonal anti-IL-22 mAb. Furthermore, data revealed that the detectable IL-22 affected the phynotype of IFN-γ(+)CD4(+)T cells. IL-22 induced up-regulation of CD27 expression in IFN-γ(+)CD4(+)T cells, which might further confirm that IL-22 had an effect on the response of IFN-γ. Thus, this work provides a previous unknown relationship between IFN-γ and IL-22 in human TB disease.

Copyright © 2012 Elsevier B.V. All rights reserved.

PMID:
23266494
[PubMed - indexed for MEDLINE]
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