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J Ethnopharmacol. 2013 Feb 13;145(3):822-5. doi: 10.1016/j.jep.2012.12.021. Epub 2012 Dec 21.

Screening of plants used in Danish folk medicine to treat depression and anxiety for affinity to the serotonin transporter and inhibition of MAO-A.

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  • 1Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2 Universitetsparken, 2100 Copenhagen O, Denmark. Electronic address: anna.jager@sund.ku.dk

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

A number of plant species are used in Danish folk medicine for treatment of depression and anxiety.

MATERIALS AND METHODS:

Aqueous and ethanolic extracts of 17 plant species were tested for affinity to the serotonin transporter and for inhibition of MAO-A-both targets for antidepressive treatment.

RESULTS:

An ethanolic extract of aerial parts of Borago officinalis had affinity to the serotonin transporter. Ten extracts, from eight plants, had IC(50) values below 25μg/ml extract in the MAO-A assay. The most active extracts in the MAO-A assay were the ethanol extract of seeds of Trigonella foenum-graecum (IC(50) 4μg/ml); ethanol extract of leaves of Apium graveolens (IC(50) 5μg/ml) and the water extract of aerial parts of Calluna vulgaris (IC(50) 8μg/ml).

CONCLUSIONS:

Besides Borago officinalis, which toxicity profile excludes it from further development as an herbal drug, none of the plants had potential as serotonin reuptake inhibitors. Several plants had MAO-A inhibitory activity.

Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PMID:
23266274
[PubMed - indexed for MEDLINE]
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