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Bioorg Med Chem Lett. 2013 Feb 1;23(3):860-3. doi: 10.1016/j.bmcl.2012.11.044. Epub 2012 Nov 29.

Discovery of nosokophic acid, a predicted intermediate of moenomycins, from nosokomycin-producing Streptomyces sp. K04-0144.

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  • 1Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Tokyo 108-8641, Japan.

Abstract

A new actinomycete metabolite designated nosokophic acid was isolated from the culture broth of nosokomycin-producing Streptomyces sp. K04-0144, and the structure was elucidated by various NMR experiments. Nosokophic acid was found to be 3-phosphoglycosyl-2-sesquiterpenyl dihydroxypropionic acid, a predicted biosynthetic intermediate of nosokomycin-related moenomycins. The compound showed no activity against MRSA, but potentiated imipenem activity against MRSA by 512-fold.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
23265883
[PubMed - indexed for MEDLINE]
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