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Bioorg Med Chem Lett. 2013 Feb 1;23(3):757-60. doi: 10.1016/j.bmcl.2012.11.078. Epub 2012 Dec 1.

Synthesis of new triazole acetamides with inotropic effects.

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  • 1Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy, Yanji 133000, PR China.

Abstract

A series of new triazole acetamides 5a-w were synthesized and evaluated for their positive inotropic activity of left atrium stroke volume on isolated rabbit-heart preparations. The majority of the derivatives presented favorable in vitro activity compared with the reference drug, milrinone. Among them triazole acetamide 5a was identified as the most potent with 20.29 ± 0.18% increased stroke volume (milrinone: 2.46 ± 0.07%) at a concentration of 3 × 10(-5) M. The chronotropic effects of the compounds having inotropic effects were also evaluated.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
23265872
[PubMed - indexed for MEDLINE]
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