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J Infect Dis. 2013 Mar 15;207(6):940-6. doi: 10.1093/infdis/jis922. Epub 2012 Dec 18.

Racial variation in toll-like receptor variants among women with pelvic inflammatory disease.

Author information

  • 1Department of Epidemiology, University of Pittsburgh, 130 Desoto St, 513 Parran Hall, Pittsburgh, PA 15261, USA. depaolib@edc.pitt.edu

Abstract

BACKGROUND:

Racial disparities exist in gynecological diseases. Variations in Toll-like receptor (TLR) genes may alter signaling following microbial recognition.

METHODS:

We explored genotypic differences in 6 functional variants in 4 TLR genes (TLR1, TLR2, TLR4, TLR6) and the adaptor molecule TIRAP between 205 African American women and 51 white women with clinically suspected pelvic inflammatory disease (PID). A permutated P < .007 was used to assess significance. Associations between race and endometritis and/or upper genital tract infection (UGTI) were explored. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS:

The TT genotype for TLR1 rs5743618, the GG genotype for TLR1 rs4833095, the CC genotype for TLR2 rs3804099, the TLR6 rs5743810 T allele, and the CC genotype for TIRAP rs8177374 significantly differed between races (P < .007). African American race was associated with endometritis and/or UGTI (OR, 4.2 [95% CI, 2.0-8.7]; P = .01). Among African Americans, the TLR6 rs5743810 T allele significantly decreased endometritis and/or UGTI (OR, 0.4 [95% CI, .2-.9]; P = .04). Additionally, rs5743618, rs4833095, and rs8177374 increased endometritis and/or UGTI, albeit not significantly.

CONCLUSIONS:

Among women with PID, TLR variants that increase inflammation are associated with African American race and may mediate the relationship between race and endometritis and/or UGTI.

PMID:
23255565
[PubMed - indexed for MEDLINE]
PMCID:
PMC3571443
Free PMC Article
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