Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Curr Pain Headache Rep. 2013 Jan;17(1):309. doi: 10.1007/s11916-012-0309-4.

Headache frontiers: using magnetoencephalography to investigate pathophysiology of chronic migraine.

Author information

  • 1Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, 201, Shihpai Rd Sec 2, Taipei, 112, Taiwan, Republic of China. wtchen@vghtpe.gov.tw


Episodic migraine (EM) may evolve into disabling chronic migraine (CM). The progression is elusive but may be underpinned by central excitability change. Recently, several studies have investigated visual cortex excitability in different migraine disorders using magnetoencephalography, a technique superior to traditional scalp electroencephalography in measuring cortical excitability. These studies replicated the earlier visual evoked potential findings that the visual excitability in EM is dynamically modulated, featured by an interictal lack and ictal recovery of the habituation (ie, response attenuation to repetitive stimulations) in visual evoked responses. Moreover, the excitability in CM presented with a persistent ictal-like dysfunction in interictal recordings, which shifted in tandem to the pattern characteristic of EM after a clinical remission from CM to EM. A sustained potentiation (response augmentation) further differentiates CM with the rare phenotype of persistent visual aura from EM or CM alone. To conclude, visual cortex excitability is a potential biomarker of migraine disorders and its neuroplasticity is associated with CM evolution or remission.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Springer
    Loading ...
    Write to the Help Desk