Bovine coronaviruses from the respiratory tract: antigenic and genetic diversity

Vaccine. 2013 Jan 30;31(6):886-92. doi: 10.1016/j.vaccine.2012.12.006. Epub 2012 Dec 14.

Abstract

BoCV isolated from respiratory tract, nasal swab and broncho alveolar washing fluid samples were evaluated for genetic and antigenic differences. These BoCV from the respiratory tract of healthy and clinically ill cattle with BRD signs were compared to reference and vaccine strains based on Spike protein coding sequences and VNT using convalescent antisera. Based on this study, the BoCV isolates belong to one of two genomic clades (clade 1 and 2) which can be differentiated antigenically. The respiratory isolates from Oklahoma in this study were further divided by genetic differences into three subclades, 2a, 2b, and 2c. Reference enteric BoCV strains and a vaccine strain were in clade 1. Currently available vaccines designed to control enteric disease are based on viruses from one clade while viruses isolated from respiratory tracts, in this study, belong to the other clade.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Viral / immunology
  • Carrier State / veterinary*
  • Carrier State / virology
  • Cattle
  • Cattle Diseases / virology*
  • Cluster Analysis
  • Coronavirus Infections / veterinary*
  • Coronavirus Infections / virology
  • Coronavirus, Bovine / classification*
  • Coronavirus, Bovine / genetics
  • Coronavirus, Bovine / immunology
  • Coronavirus, Bovine / isolation & purification
  • Genetic Variation*
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Viral / genetics
  • Respiratory System / virology*
  • Respiratory Tract Infections / veterinary*
  • Respiratory Tract Infections / virology
  • Sequence Analysis, DNA
  • United States

Substances

  • Antigens, Viral
  • RNA, Viral

Associated data

  • GENBANK/JQ741947
  • GENBANK/JQ741948
  • GENBANK/JQ741949
  • GENBANK/JQ741950
  • GENBANK/JQ741951
  • GENBANK/JQ741952
  • GENBANK/JQ741953
  • GENBANK/JQ741954
  • GENBANK/JQ741955
  • GENBANK/JQ741956
  • GENBANK/JQ741957
  • GENBANK/JQ741958
  • GENBANK/JQ741959
  • GENBANK/JQ741960
  • GENBANK/JQ741961
  • GENBANK/JQ741962
  • GENBANK/JQ741963
  • GENBANK/JQ741964
  • GENBANK/JQ741965
  • GENBANK/JQ741966
  • GENBANK/JQ741967
  • GENBANK/JQ741968
  • GENBANK/JQ741969
  • GENBANK/JQ741970
  • GENBANK/JX536392