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Mol Cell. 2013 Jan 24;49(2):262-72. doi: 10.1016/j.molcel.2012.11.013. Epub 2012 Dec 13.

Latent regulatory potential of human-specific repetitive elements.

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  • 1University of Cambridge, Cancer Research UK-Cambridge Institute, Cambridge CB2 0RE, UK.

Abstract

At least half of the human genome is derived from repetitive elements, which are often lineage specific and silenced by a variety of genetic and epigenetic mechanisms. Using a transchromosomic mouse strain that transmits an almost complete single copy of human chromosome 21 via the female germline, we show that a heterologous regulatory environment can transcriptionally activate transposon-derived human regulatory regions. In the mouse nucleus, hundreds of locations on human chromosome 21 newly associate with activating histone modifications in both somatic and germline tissues, and influence the gene expression of nearby transcripts. These regions are enriched with primate and human lineage-specific transposable elements, and their activation corresponds to changes in DNA methylation at CpG dinucleotides. This study reveals the latent regulatory potential of the repetitive human genome and illustrates the species specificity of mechanisms that control it.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23246434
[PubMed - indexed for MEDLINE]
PMCID:
PMC3560060
Free PMC Article

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