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Results: 20

1.

Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models.

Corcoran RB, Cheng KA, Hata AN, Faber AC, Ebi H, Coffee EM, Greninger P, Brown RD, Godfrey JT, Cohoon TJ, Song Y, Lifshits E, Hung KE, Shioda T, Dias-Santagata D, Singh A, Settleman J, Benes CH, Mino-Kenudson M, Wong KK, Engelman JA.

Cancer Cell. 2013 Jan 14;23(1):121-8. doi: 10.1016/j.ccr.2012.11.007. Epub 2012 Dec 13.

2.

Keap1: one stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL.

Tian H, Zhang B, Di J, Jiang G, Chen F, Li H, Li L, Pei D, Zheng J.

Cancer Lett. 2012 Dec 1;325(1):26-34. doi: 10.1016/j.canlet.2012.06.007. Epub 2012 Jun 26. Review.

PMID:
22743616
3.

Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S.

Cancer Res. 2013 Feb 15;73(4):1340-51. doi: 10.1158/0008-5472.CAN-12-1365. Epub 2012 Dec 12.

4.

Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency.

Wei G, Margolin AA, Haery L, Brown E, Cucolo L, Julian B, Shehata S, Kung AL, Beroukhim R, Golub TR.

Cancer Cell. 2012 Apr 17;21(4):547-62. doi: 10.1016/j.ccr.2012.02.028.

5.

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.

Follis AV, Chipuk JE, Fisher JC, Yun MK, Grace CR, Nourse A, Baran K, Ou L, Min L, White SW, Green DR, Kriwacki RW.

Nat Chem Biol. 2013 Mar;9(3):163-8. doi: 10.1038/nchembio.1166. Epub 2013 Jan 20.

6.

Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis.

Zhou F, Yang Y, Xing D.

FEBS J. 2011 Feb;278(3):403-13. doi: 10.1111/j.1742-4658.2010.07965.x. Epub 2010 Dec 23. Review.

PMID:
21182587
7.

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.

Alavian KN, Li H, Collis L, Bonanni L, Zeng L, Sacchetti S, Lazrove E, Nabili P, Flaherty B, Graham M, Chen Y, Messerli SM, Mariggio MA, Rahner C, McNay E, Shore GC, Smith PJ, Hardwick JM, Jonas EA.

Nat Cell Biol. 2011 Sep 18;13(10):1224-33. doi: 10.1038/ncb2330. Erratum in: Nat Cell Biol. 2011 Nov;13(11):1383.

8.

PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage.

Arena G, Gelmetti V, Torosantucci L, Vignone D, Lamorte G, De Rosa P, Cilia E, Jonas EA, Valente EM.

Cell Death Differ. 2013 Jul;20(7):920-30. doi: 10.1038/cdd.2013.19. Epub 2013 Mar 22.

9.

The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition.

Peddaboina C, Jupiter D, Fletcher S, Yap JL, Rai A, Tobin RP, Jiang W, Rascoe P, Rogers MK, Smythe WR, Cao X.

BMC Cancer. 2012 Nov 21;12:541. doi: 10.1186/1471-2407-12-541.

10.

Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B.

Rooswinkel RW, van de Kooij B, Verheij M, Borst J.

Cell Death Dis. 2012 Aug 9;3:e366. doi: 10.1038/cddis.2012.109.

11.

Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis.

Niture SK, Jaiswal AK.

J Biol Chem. 2011 Dec 30;286(52):44542-56. doi: 10.1074/jbc.M111.275073. Epub 2011 Nov 9. Retraction in: J Biol Chem. 2014 Aug 8;289(32):22019.

12.

Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets.

Kraemer BF, Campbell RA, Schwertz H, Franks ZG, Vieira de Abreu A, Grundler K, Kile BT, Dhakal BK, Rondina MT, Kahr WH, Mulvey MA, Blaylock RC, Zimmerman GA, Weyrich AS.

Blood. 2012 Dec 13;120(25):5014-20. doi: 10.1182/blood-2012-04-420661. Epub 2012 Oct 18.

13.

Bcl-2 and Bcl-xL suppress glucose signaling in pancreatic β-cells.

Luciani DS, White SA, Widenmaier SB, Saran VV, Taghizadeh F, Hu X, Allard MF, Johnson JD.

Diabetes. 2013 Jan;62(1):170-82. doi: 10.2337/db11-1464. Epub 2012 Aug 28.

14.

Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.

Yi CH, Pan H, Seebacher J, Jang IH, Hyberts SG, Heffron GJ, Vander Heiden MG, Yang R, Li F, Locasale JW, Sharfi H, Zhai B, Rodriguez-Mias R, Luithardt H, Cantley LC, Daley GQ, Asara JM, Gygi SP, Wagner G, Liu CF, Yuan J.

Cell. 2011 Aug 19;146(4):607-20. doi: 10.1016/j.cell.2011.06.050.

15.

Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells.

Aranovich A, Liu Q, Collins T, Geng F, Dixit S, Leber B, Andrews DW.

Mol Cell. 2012 Mar 30;45(6):754-63. doi: 10.1016/j.molcel.2012.01.030.

16.

Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter.

Latha K, Li M, Chumbalkar V, Gururaj A, Hwang Y, Dakeng S, Sawaya R, Aldape K, Cavenee WK, Bogler O, Furnari FB.

Int J Cancer. 2013 Feb 1;132(3):509-20. doi: 10.1002/ijc.27690. Epub 2012 Jul 9. Erratum in: Int J Cancer. 2015 Sep;137(6):E10-1.

17.

Quercetin potentiates doxorubicin mediated antitumor effects against liver cancer through p53/Bcl-xl.

Wang G, Zhang J, Liu L, Sharma S, Dong Q.

PLoS One. 2012;7(12):e51764. doi: 10.1371/journal.pone.0051764. Epub 2012 Dec 11.

18.

Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.

Kodama T, Hikita H, Kawaguchi T, Shigekawa M, Shimizu S, Hayashi Y, Li W, Miyagi T, Hosui A, Tatsumi T, Kanto T, Hiramatsu N, Kiyomizu K, Tadokoro S, Tomiyama Y, Hayashi N, Takehara T.

Cell Death Differ. 2012 Nov;19(11):1856-69. doi: 10.1038/cdd.2012.88. Epub 2012 Jul 13.

19.

Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level.

Kwon OH, Kang TW, Kim JH, Kim M, Noh SM, Song KS, Yoo HS, Kim WH, Xie Z, Pocalyko D, Kim SY, Kim YS.

Biochem Biophys Res Commun. 2012 Jun 22;423(1):38-44. doi: 10.1016/j.bbrc.2012.05.063. Epub 2012 May 22.

PMID:
22627140
20.

N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death.

Ofengeim D, Chen YB, Miyawaki T, Li H, Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman JA, Hardwick JM, Zukin RS, Jonas EA.

Nat Neurosci. 2012 Feb 26;15(4):574-80. doi: 10.1038/nn.3054.

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