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Results: 20

1.

Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models.

Corcoran RB, Cheng KA, Hata AN, Faber AC, Ebi H, Coffee EM, Greninger P, Brown RD, Godfrey JT, Cohoon TJ, Song Y, Lifshits E, Hung KE, Shioda T, Dias-Santagata D, Singh A, Settleman J, Benes CH, Mino-Kenudson M, Wong KK, Engelman JA.

Cancer Cell. 2013 Jan 14;23(1):121-8. doi: 10.1016/j.ccr.2012.11.007. Epub 2012 Dec 13.

PMID:
23245996
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Keap1: one stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL.

Tian H, Zhang B, Di J, Jiang G, Chen F, Li H, Li L, Pei D, Zheng J.

Cancer Lett. 2012 Dec 1;325(1):26-34. doi: 10.1016/j.canlet.2012.06.007. Epub 2012 Jun 26. Review.

PMID:
22743616
[PubMed - indexed for MEDLINE]
3.

Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency.

Wei G, Margolin AA, Haery L, Brown E, Cucolo L, Julian B, Shehata S, Kung AL, Beroukhim R, Golub TR.

Cancer Cell. 2012 Apr 17;21(4):547-62. doi: 10.1016/j.ccr.2012.02.028.

PMID:
22516262
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S.

Cancer Res. 2013 Feb 15;73(4):1340-51. doi: 10.1158/0008-5472.CAN-12-1365. Epub 2012 Dec 12.

PMID:
23243017
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis.

Zhou F, Yang Y, Xing D.

FEBS J. 2011 Feb;278(3):403-13. doi: 10.1111/j.1742-4658.2010.07965.x. Epub 2010 Dec 23. Review.

PMID:
21182587
[PubMed - indexed for MEDLINE]
6.

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.

Alavian KN, Li H, Collis L, Bonanni L, Zeng L, Sacchetti S, Lazrove E, Nabili P, Flaherty B, Graham M, Chen Y, Messerli SM, Mariggio MA, Rahner C, McNay E, Shore GC, Smith PJ, Hardwick JM, Jonas EA.

Nat Cell Biol. 2011 Sep 18;13(10):1224-33. doi: 10.1038/ncb2330. Erratum in: Nat Cell Biol. 2011 Nov;13(11):1383.

PMID:
21926988
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis.

Niture SK, Jaiswal AK.

J Biol Chem. 2011 Dec 30;286(52):44542-56. doi: 10.1074/jbc.M111.275073. Epub 2011 Nov 9. Retraction in: J Biol Chem. 2014 Aug 8;289(32):22019.

PMID:
22072718
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level.

Kwon OH, Kang TW, Kim JH, Kim M, Noh SM, Song KS, Yoo HS, Kim WH, Xie Z, Pocalyko D, Kim SY, Kim YS.

Biochem Biophys Res Commun. 2012 Jun 22;423(1):38-44. doi: 10.1016/j.bbrc.2012.05.063. Epub 2012 May 22.

PMID:
22627140
[PubMed - indexed for MEDLINE]
9.

Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells.

Aranovich A, Liu Q, Collins T, Geng F, Dixit S, Leber B, Andrews DW.

Mol Cell. 2012 Mar 30;45(6):754-63. doi: 10.1016/j.molcel.2012.01.030.

PMID:
22464442
[PubMed - indexed for MEDLINE]
Free Article
10.

Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein.

Arbel N, Ben-Hail D, Shoshan-Barmatz V.

J Biol Chem. 2012 Jun 29;287(27):23152-61. doi: 10.1074/jbc.M112.345918. Epub 2012 May 15.

PMID:
22589539
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.

Yi CH, Pan H, Seebacher J, Jang IH, Hyberts SG, Heffron GJ, Vander Heiden MG, Yang R, Li F, Locasale JW, Sharfi H, Zhai B, Rodriguez-Mias R, Luithardt H, Cantley LC, Daley GQ, Asara JM, Gygi SP, Wagner G, Liu CF, Yuan J.

Cell. 2011 Aug 19;146(4):607-20. doi: 10.1016/j.cell.2011.06.050.

PMID:
21854985
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.

Follis AV, Chipuk JE, Fisher JC, Yun MK, Grace CR, Nourse A, Baran K, Ou L, Min L, White SW, Green DR, Kriwacki RW.

Nat Chem Biol. 2013 Mar;9(3):163-8. doi: 10.1038/nchembio.1166. Epub 2013 Jan 20.

PMID:
23340338
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Distinct roles of mitochondria- and ER-localized Bcl-xL in apoptosis resistance and Ca2+ homeostasis.

Eno CO, Eckenrode EF, Olberding KE, Zhao G, White C, Li C.

Mol Biol Cell. 2012 Jul;23(13):2605-18. doi: 10.1091/mbc.E12-02-0090. Epub 2012 May 9.

PMID:
22573883
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B.

Rooswinkel RW, van de Kooij B, Verheij M, Borst J.

Cell Death Dis. 2012 Aug 9;3:e366. doi: 10.1038/cddis.2012.109.

PMID:
22875003
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death.

Ofengeim D, Chen YB, Miyawaki T, Li H, Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman JA, Hardwick JM, Zukin RS, Jonas EA.

Nat Neurosci. 2012 Feb 26;15(4):574-80. doi: 10.1038/nn.3054.

PMID:
22366758
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets.

Kraemer BF, Campbell RA, Schwertz H, Franks ZG, Vieira de Abreu A, Grundler K, Kile BT, Dhakal BK, Rondina MT, Kahr WH, Mulvey MA, Blaylock RC, Zimmerman GA, Weyrich AS.

Blood. 2012 Dec 13;120(25):5014-20. doi: 10.1182/blood-2012-04-420661. Epub 2012 Oct 18.

PMID:
23086749
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential.

Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM.

J Cell Biol. 2011 Oct 17;195(2):263-76. doi: 10.1083/jcb.201108059. Epub 2011 Oct 10.

PMID:
21987637
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Bcl-2 and Bcl-xL suppress glucose signaling in pancreatic β-cells.

Luciani DS, White SA, Widenmaier SB, Saran VV, Taghizadeh F, Hu X, Allard MF, Johnson JD.

Diabetes. 2013 Jan;62(1):170-82. doi: 10.2337/db11-1464. Epub 2012 Aug 28.

PMID:
22933114
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition.

Peddaboina C, Jupiter D, Fletcher S, Yap JL, Rai A, Tobin RP, Jiang W, Rascoe P, Rogers MK, Smythe WR, Cao X.

BMC Cancer. 2012 Nov 21;12:541. doi: 10.1186/1471-2407-12-541.

PMID:
23171055
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Escape from p21-mediated oncogene-induced senescence leads to cell dedifferentiation and dependence on anti-apoptotic Bcl-xL and MCL1 proteins.

de Carné Trécesson S, Guillemin Y, Bélanger A, Bernard AC, Preisser L, Ravon E, Gamelin E, Juin P, Barré B, Coqueret O.

J Biol Chem. 2011 Apr 15;286(15):12825-38. doi: 10.1074/jbc.M110.186437. Epub 2011 Feb 3.

PMID:
21292770
[PubMed - indexed for MEDLINE]
Free PMC Article

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