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Org Lett. 2013 Jan 4;15(1):100-3. doi: 10.1021/ol3031318. Epub 2012 Dec 14.

Phosphoiodyns A and B, unique phosphorus-containing iodinated polyacetylenes from a Korean sponge Placospongia sp.

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  • 1Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul, 151-747, Korea.

Erratum in

  • Org Lett. 2013 Nov 1;15(21):5614.


Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1-2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPAR╬┤) with an EC(50) of 23.7 nM.

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