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In Vivo. 2013 Jan-Feb;27(1):107-11.

Effects of purified glycerol from biodiesel on miRNAs compared to the expression profile of selected mRNAs in Balb/c mice.

Author information

  • 1Institute of Public Health, Faculty of Medicine, University of Pécs, Pécs, 12 Szigeti str., 7624 Hungary. eszter.szele@gmail.com

Abstract

BACKGROUND:

We investigated the effect of corn-derived biodiesel glycerol on microRNAs (miRNAs) and mRNAs, which play a central role in regulating cell survival, apoptosis and carcinogenesis.

MATERIALS AND METHODS:

Inbred Balb/c mice were treated with purified glycerol from biodiesel for 24 hours. After administration, we determined the expressions of miR-21, miR-27a, miR-34a, miR-93, miR-143, miR-146a, miR-148a, miR-155, miR-196a, miR-203, miR-205, miR-221 and nuclear factor kappa-light-chain enhancer of activated B-cells-1 (Nfκb1), mitogen-activated protein kinase-8 (Mapk8) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (K-ras) genes in the liver of mice.

RESULTS:

We found a parallel altered expression of miRNAs and mRNAs in animals consuming biodiesel glycerol that compared to control mice; these alterations reached significant levels only in few cases.

CONCLUSION:

Biodiesel glycerol presents no higher risk for carcinogenicity or toxicity.

PMID:
23239858
[PubMed - indexed for MEDLINE]
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