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Masui. 2012 Nov;61(11):1221-5.

[Is nitrous oxide useful for laryngeal mask airway insertion under 8% sevoflurane?].

[Article in Japanese]

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  • 1Department of Anesthesiology and Critical Care, Higashi Omiya General Hospital, Saitama 337-0051.



The usefulness of nitrous oxide for laryngeal mask airway insertion under 8% sevoflurane anesthesia was investigated.


One hundred and fifty patients aged 40 to 60 years for general anesthesia were divided into GOS (nitrous oxide, oxygen, sevoflurane) and OS (oxygen, sevoflurane) groups. Anesthesia was induced with 8% sevoflurane and nitrous oxide 3 l x min(-1) and oxygen 3 l x min(-1) in the GOS group, or oxygen 6 l x min(-1) in the OS group. When verbal response disappeared, sevoflurane concentration was reduced to 3%. Five min after the start of induction, laryngeal mask airway was inserted.


The changes in blood pressure and heart rate were significantly smaller and times to disappearance of eyelash response and verbal response were significantly shorter in the GOS group than those in the OS group. The frequencies of postoperative nausea, vomiting, and headache were not different between the groups.


Nitrous oxide shortened induction time, decreased hemodynamic changes, but did not increase postoperative nausea, vomiting and headache when used for anesthesia induction with 8% sevoflurane to insert laryngeal mask airway.

[PubMed - indexed for MEDLINE]
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