Abstract
Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [(18)F], was synthesised in radiofluorinated form. PET/CT Imaging with [(18)F] identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.
MeSH terms
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Alzheimer Disease / diagnosis
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Alzheimer Disease / diagnostic imaging*
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Alzheimer Disease / genetics
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Amyloid beta-Peptides / analysis*
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Amyloid beta-Peptides / genetics
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Animals
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Barbiturates* / chemistry
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Brain / diagnostic imaging*
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Brain / metabolism
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Fluorine Radioisotopes* / chemistry
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Humans
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Plaque, Amyloid / diagnostic imaging*
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Plaque, Amyloid / genetics
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Positron-Emission Tomography / methods
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Up-Regulation
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tau Proteins / analysis
Substances
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Amyloid beta-Peptides
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Barbiturates
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Fluorine Radioisotopes
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tau Proteins