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J Alzheimers Dis. 2013;34(2):457-68. doi: 10.3233/JAD-122059.

Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807.

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  • 1Siemens Molecular Imaging, Inc., Culver City, CA 90230, USA.

Abstract

Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807, which may be useful for imaging Alzheimer's disease and other tauopathies. Here in, we describe the first human brain images with [F-18]-T807.

PMID:
23234879
[PubMed - indexed for MEDLINE]
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