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Zhongguo Zhong Yao Za Zhi. 2012 Aug;37(16):2465-8.

[Clinical study on prevention efficacy of Jianpi Huatan Fang in treating non-alcoholic fatty liver disease in children].

[Article in Chinese]

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  • 1Affiliated Children's Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.



To verify the clinical efficacy of Jianpi Huatan Fang in treating non-alcoholic fatty liver disease in children.


Sixty children patients with non-alcoholic liver disease were randomly assigned to 2 groups of 30 patients each , being treated with Jianpi Huatan Fang and the Vitamin E Recipe with a span of 3 months, respectively. The changes of the FINS, FPG, AST, ALT, TG, CHO, HDL, LDL, HOMA-IR, IAI after and before the treatments in both groups as well as the ultrasound imaging changes of liver were observed.


The Chinese medicine group saw higher total effective rate (83.3%) than the Vitamin E group (46.7%) with statistic difference. In addition, after the treatments, both groups saw the significant decrease of the levels of serum lipid metabolic indexes and insulin resistance indexes. Both treatments could effectively enhance the function of liver, but Chinese medicine showed better efficacy. The Chinese medicine group also saw the decrease of ATC, TG, LDL and increase of HDL-C (P < 0.05 (see character in text) P <0.01) after the treatment, showing that the Chinese medicine could effectively enhance blood fat; while the Vit E group did not showed improvement in TC, LDL-C, HDL-C.


Jianpi Huatan Fang showed good efficacy in treating non-alcoholic fatty liver in children with no observable toxic side effects, thus clinic use shall be recommended.

[PubMed - indexed for MEDLINE]
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